Colchicine is used for treating and preventing gout flares.
Can you buy colchicine over the counter anywhere? There was only one site that listed it. Why would it be like that?" In short, for some of the people who got infected, "it didn't work," says Dr. Sacco.
But for more than a quarter of all people, it did.
Dr. Sacco didn't believe the study was that conclusive, nor did the other authors he contacted â€” but went ahead anyway by repeating the results on his medical network. The result: same results.
For these people, Sacco says, colchicine really did work, and it work for them. As a result, all practical purposes, they now have colchicine prescription-only.
The question remains: Does it work for you? The most convincing data â€” including the one Dr. Sacco got himself â€” is that it doesn't.
For more than 20 years, the FDA's advisory committee on medical devices had asked questions about colchicine. It had asked whether it's worth recommending it for routine use in the United States and whether it is any better for people than a placebo. The answer to both of those questions, the FDA said, was no.
The FDA's statement has been challenged. A group of doctors and the American Health Information Service, a nonprofit health-care have asked two prominent academic medical centers in Minnesota and Florida, Johns Hopkins the University of Miami, to conduct their own studies of colchicine's efficacy.
Both have declined â€” but it's not clear whether the government agency will.
FDA spokeswoman Jessica Rich said agency scientists are gathering data to determine if any new data would require buy colchicine 500 microgram tablets approval. "But FDA generally doesn't take action against a drug," she said.
If the research is inconclusive, however, some experts say, the FDA could consider revoking drug. If it is good for a minority â€” which the FDA says it is â€” can't Is generic fluconazole as good as diflucan be recommended for the other 95 percent of people, says James Creswell, a University of Texas researcher who is a proponent of the drug, which he calls a "minimally effective treatment."
If the drug were to be made available people like those who developed hepatitis C, for example, it could increase their risks as much 70 percent, according to the Centers for Disease Control and Prevention.
For these reasons, the federal advisory committee on medical devices, in which Sacco himself serves, has long considered the drug a "nuisance case" and said doctors colchicine buy should not be forced to prescribe it. In May 2000, when the FDA released its conclusions â€” with which it agreed, but only in part â€” it said doctors shouldn't prescribe colchicine, and recommended that the drug be placed in an off-label category reserved for drugs that are "unlikely to be curative" when they are prescribed by "appropriate practitioners."
A study published by Dr. Sacco's medical network in February of this year suggests the FDA may have been more concerned about giving the drug to unwell â€” but its conclusions are not definitive. The study, in Journal of Pharmaceutical Industry, followed 13 people who started taking colchicine to cure their hepatitis C. They were followed for two years, Colchicine 0.5mg $65.01 - $0.72 Per pill and the people who started using it reported no new infections.
"The study is consistent with the Best price for viagra in canada FDA's finding that there is no effective treatment for hepatitis C," said Dr. David C. Jellott, the medical director of a research project supported by the FDA and Institute of Human Development in San Francisco. The study is currently under review by the FDA.
Jellott and others at the FDA's Center for Drug Evaluation and Research told the group of doctors at FDA Forum that the results of study may well reflect what other countries in Europe are seeing already, including patients receiving colchicine therapy.
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